Publications

Mechanism of action of Icerguastat (sephin1 or IFB-088)

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. DOI: 1126/science.aaa4484 https://pubmed.ncbi.nlm.nih.gov/25859045/

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors. DOI: 1038/nsmb.3443
https://pubmed.ncbi.nlm.nih.gov/28759048/

Sephin1 protects neurons against excitotoxicity independently of the Integrated Stress Response. DOI: 3390/ijms21176088 https://pubmed.ncbi.nlm.nih.gov/32846985/

Sephin1 suppresses ER stress-induced cell death by inhibiting the formation of PP2A holoenzyme. DOI: 1038/s41419-025-07450-1 https://pubmed.ncbi.nlm.nih.gov/39971896/

Amyotrophic Lateral Sclerosis (ALS)

Sephin1 reduces TDP-43 cytoplasmic mislocalization and improves motor neuron survival in ALS models. DOI: 10.26508/lsa.202403195 https://pubmed.ncbi.nlm.nih.gov/40602832/

Sephin1 protects neurons against excitotoxicity independently of the Integrated Stress Response. DOI: 10.3390/ijms21176088 https://pubmed.ncbi.nlm.nih.gov/32846985/

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. DOI: 10.1126/science.aaa4484 https://pubmed.ncbi.nlm.nih.gov/25859045/

Harnessing osmotic shock for enhanced intracellular delivery of (nano)cargos. DOI: 10.1016/j.ijpharm.2024.125008 https://pubmed.ncbi.nlm.nih.gov/39638270/

Charcot-Marie-Tooth (CMT)

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. DOI: 1126/science.aaa4484 https://pubmed.ncbi.nlm.nih.gov/25859045/

Treatment with IFB-088 improves neuropathy in CMT1A and CMT1B mice. DOI: 1007/s12035-022-02838-y
https://pubmed.ncbi.nlm.nih.gov/35501630/

Alzheimer Disease (AD)

Amyloid Aβ25-35 aggregates say ‘NO’ to long-term potentiation in the hippocampus through activation of stress-induced phosphatase 1 and mitochondrial Na+/Ca2+ exchanger. DOI: 3390/ijms231911848 https://pubmed.ncbi.nlm.nih.gov/36233148/

Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis. DOI: 1091/mbc.E21-11-0553 https://pubmed.ncbi.nlm.nih.gov/35446108/

Multiple Sclerosis (MS)

Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the Integrated Stress Response. DOI: 1002/glia.24386 – https://pubmed.ncbi.nlm.nih.gov/37203250/

Prolonging the Integrated Stress Response enhances CNS remyelination in an inflammatory environment. DOI: 7554/eLife.65469 https://pubmed.ncbi.nlm.nih.gov/33752802/

Sephin1, which prolongs the Integrated Stress Response, is a promising therapeutic for multiple sclerosis. DOI: 1093/brain/awy322 https://pubmed.ncbi.nlm.nih.gov/30657878/

Spastic Ataxia-5 (SPAX5)

Sustained OMA1-mediated Integrated Stress Response is beneficial for spastic ataxia type 5. DOI: 1093/brain/awad340 https://pubmed.ncbi.nlm.nih.gov/37804316/

Inflammation

A novel, rapid, and practical prognostic model for sepsis patients based on dysregulated immune cell lactylation. DOI: 3389/fimmu.2025.1625311 https://pubmed.ncbi.nlm.nih.gov/40612938/